Definition: Panama Seco: Seco ("dry") is the official beverage of Panama. Distilled from sugar cane, seco is a clear 80 proof liquor, typically used in place of vodka or rum in cocktails. It's also often mixed with milk. Seco Herrerano is the most popular brand of seco, brewed by the same family who invented seco in Panama in 1908. In Panama, seco is often sold packaged together with a mixer.